2. PROTAC
  3. PROTAC Linkers
  4. PEG-bis-amine (MW 20000)

PEG-bis-amine (MW 20000)  (Synonyms: Poly(ethylene glycol)-bis-amine (MW 20000))

Cat. No.: HY-140649 Purity: ≥98.0%
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PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

PEG-bis-amine (MW 20000) Chemical Structure

PEG-bis-amine (MW 20000) Chemical Structure

CAS No. : 24991-53-5

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Based on 1 publication(s) in Google Scholar

PEG-bis-amine (MW 20000) Related Antibodies

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Description

PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PEG-bis-amine (MW 20000) Related Antibodies
Molecular Weight

20000(Average)

Formula

(C2H4O)nC4H12N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCOCCOCCN.[n]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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PEG-bis-amine (MW 20000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEG-bis-amine (MW 20000)24991-53-5Poly(ethylene glycol)-bis-amine (MW 20000)PROTAC LinkersInhibitorinhibitorinhibit

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