2. PROTAC
  3. PROTAC Linkers
  4. PEG6-(CH2CO2H)2

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

For research use only. We do not sell to patients.

PEG6-(CH2CO2H)2 Chemical Structure

PEG6-(CH2CO2H)2 Chemical Structure

CAS No. : 77855-76-6

Size Price Stock Quantity
25 mg USD 42 In-stock
50 mg USD 70 In-stock
100 mg USD 110 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PEG6-(CH2CO2H)2 Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].

IC50 & Target

PEGs

 

Molecular Weight

354.35

Formula

C14H26O10
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(O)COCCOCCOCCOCCOCCOCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (282.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8221 mL 14.1103 mL 28.2207 mL
5 mM 0.5644 mL 2.8221 mL 5.6441 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 2.8221 mL 14.1103 mL 28.2207 mL 70.5517 mL
5 mM 0.5644 mL 2.8221 mL 5.6441 mL 14.1103 mL
10 mM 0.2822 mL 1.4110 mL 2.8221 mL 7.0552 mL
15 mM 0.1881 mL 0.9407 mL 1.8814 mL 4.7034 mL
20 mM 0.1411 mL 0.7055 mL 1.4110 mL 3.5276 mL
25 mM 0.1129 mL 0.5644 mL 1.1288 mL 2.8221 mL
30 mM 0.0941 mL 0.4703 mL 0.9407 mL 2.3517 mL
40 mM 0.0706 mL 0.3528 mL 0.7055 mL 1.7638 mL
50 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4110 mL
60 mM 0.0470 mL 0.2352 mL 0.4703 mL 1.1759 mL
80 mM 0.0353 mL 0.1764 mL 0.3528 mL 0.8819 mL
100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PEG6-(CH2CO2H)2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEG6-(CH2CO2H)277855-76-6PROTAC LinkersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PEG6-(CH2CO2H)2
Cat. No.:
HY-122702
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.