2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. PEN (rat)

PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.

For research use only. We do not sell to patients.

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PEN (rat) Chemical Structure

PEN (rat) Chemical Structure

CAS No. : 569364-13-2

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1 mg USD 220 In-stock
5 mg USD 572 In-stock
10 mg USD 850 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PEN (rat):

PEN (rat) Related Antibodies

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Description

PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

In Vitro

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN[2].
PEN binds and activates a GPCR in the brain[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PEN (rat) Related Antibodies
Molecular Weight

2301.59

Formula

C102H169N27O33
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ala-Val-Asp-Gln-Asp-Leu-Gly-Pro-Glu-Val-Pro-Pro-Glu-Asn-Val-Leu-Gly-Ala-Leu-Leu-Arg-Val
Sequence Shortening

AVDQDLGPEVPPENVLGALLRV
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (21.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4345 mL 2.1724 mL 4.3448 mL
5 mM 0.0869 mL 0.4345 mL 0.8690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4345 mL 2.1724 mL 4.3448 mL 10.8621 mL
5 mM 0.0869 mL 0.4345 mL 0.8690 mL 2.1724 mL
10 mM 0.0434 mL 0.2172 mL 0.4345 mL 1.0862 mL
15 mM 0.0290 mL 0.1448 mL 0.2897 mL 0.7241 mL
20 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5431 mL
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PEN (rat) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEN (rat)569364-13-2G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1GPR83GPCRInhibitorinhibitorinhibit

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