Pendulone

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Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity.

For research use only. We do not sell to patients.

Pendulone Chemical Structure

CAS No. : 69359-09-7

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5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31

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Biological Activity
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References
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Description

Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity^[1]^[2].

IC₅₀ & Target

Plasmodium

Leishmania

In Vitro

Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC₅₀ value 19.6 µM^[1].
Pendulone displays an IC₅₀ value of 0.43 µg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC₅₀ of 1.44 µg/mL)^[2].
Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC₅₀ values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)^[2].
Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

316.31

Formula

C₁₇H₁₆O₆

CAS No.

69359-09-7

SMILES

O=C1C(OC)=C(OC)C(C(C2COC3=CC(O)=CC=C3C2)=C1)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Qingxi Su, et al. Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata. Planta Med. 2015 Aug;81(12-13):1128-32. [Content Brief]

[2]. Aziz A Rahman, et al. Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi. Nat Prod Commun. 2011 Nov;6(11):1645-50. [Content Brief]

[3]. T Konoshima, et al. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol Pharm Bull. 1997 Aug;20(8):865-8. [Content Brief]

Pendulone Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pendulone69359-09-7ParasiteBacterialantileishmanialantibacterialanticancerantiplasmodialisoflavanquinoneInhibitorinhibitorinhibit

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