2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Pentapeptide-3

Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pentapeptide-3 Chemical Structure

Pentapeptide-3 Chemical Structure

CAS No. : 135679-88-8

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Based on 1 publication(s) in Google Scholar

Pentapeptide-3 Related Antibodies

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Description

Pentapeptide-3 is a pentapeptide fragment of neurotoxin waglerin-1, it can be extracted from the venom of Temple Viper. Pentapeptide-3 is a competitive antagonist of nicotinic acetylcholine receptors (nAChRs), it can blocks nerves at the post-synaptic membrane. Pentapeptide-3 has anti-aging effects and it can be used together with other cosmetic peptides[1][2].

Molecular Weight

495.58

Formula

C21H37N9O5
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Pro-Arg-Pro-Ala-NH2
Sequence Shortening

GPRPA-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (201.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0178 mL 10.0892 mL 20.1784 mL
5 mM 0.4036 mL 2.0178 mL 4.0357 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0178 mL 10.0892 mL 20.1784 mL 50.4459 mL
5 mM 0.4036 mL 2.0178 mL 4.0357 mL 10.0892 mL
10 mM 0.2018 mL 1.0089 mL 2.0178 mL 5.0446 mL
15 mM 0.1345 mL 0.6726 mL 1.3452 mL 3.3631 mL
20 mM 0.1009 mL 0.5045 mL 1.0089 mL 2.5223 mL
25 mM 0.0807 mL 0.4036 mL 0.8071 mL 2.0178 mL
30 mM 0.0673 mL 0.3363 mL 0.6726 mL 1.6815 mL
40 mM 0.0504 mL 0.2522 mL 0.5045 mL 1.2611 mL
50 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0089 mL
60 mM 0.0336 mL 0.1682 mL 0.3363 mL 0.8408 mL
80 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6306 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5045 mL
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Pentapeptide-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentapeptide-3135679-88-8Pentapeptide3Pentapeptide 3nAChRNicotinic acetylcholine receptorsnAChRscosmetic peptidespentapeptideantagonistInhibitorinhibitorinhibit

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