2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. Pep19-2.5

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis.

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Pep19-2.5 Chemical Structure

Pep19-2.5 Chemical Structure

CAS No. : 1322711-38-5

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Based on 1 publication(s) in Google Scholar

Pep19-2.5 Related Antibodies

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Description

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1].

In Vivo

Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sepsis model in male New Zealand rabbits (2-2.5 kg)[2]
Dosage: 5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL
Administration: Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min)
Result: Killed bacteria and eliminates bacteremia 30 min post challenge;
Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge;
Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α);
And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.
Molecular Weight

2712.23

Formula

C135H187N37O22S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GCKKYRRFRWKFKGKFWFWG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Pep19-2.5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pep19-2.51322711-38-5Pyroptosislipopeptideslipopolysaccharidespattern recognition receptorsPRRsLPSLPinflammationsepsis modelInhibitorinhibitorinhibit

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