Pep63 

Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research^[1].

Pep63 can block the interaction of EphB2-ADDLs (Aβ-derived diffusible ligands) effectively and reverse impaired memory deficits in early AD mouse models by stereotactic administration into the dorsal hippocampus^[1].
Transferrin-liposome is a carrier for the delivery of Pep63 to the brain by transferrin receptor (TfR)-mediated transcytosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1146.34

C₅₁H₈₇N₁₇O₁₃

1781242-18-9

Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala

VFQVRARTVA

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N

Room temperature in continental US; may vary elsewhere.

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• [1]. Yang X, et al. Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models. Cell Death Discov. 2021 Sep 21;7(1):256.  [Content Brief]