2. Peptides
  3. Peptide and Derivatives
  4. Peptides for Drug Delivery
  5. Responsive Peptides

Responsive Peptides

Custom Peptide Synthesis

Responsive peptides are short peptides that undergo structural change functional changes in response to specific stimuli, such as pH, enzyme, temperature, etc. These peptides are being applied as carriers for drug delivery, biosensors, and diagnostics.

Responsive Peptides (8):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P4116
    pH-Low Insertion Peptide 2293160-09-3 98.35%
    pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors.
    pH-Low Insertion Peptide
  • HY-P5423A
    GALA TFA 99.34%
    GALA (TFA) is a biological active peptide (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.).
    GALA TFA
  • HY-P5423
    GALA 107658-43-5 99.04%
    GALA is a biological active peptide. (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.)
    GALA
  • HY-P4116A
    pH-Low Insertion Peptide TFA
    pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors.
    pH-Low Insertion Peptide TFA
  • HY-P3401
    GHGVYGHGVYGHGPYGHGPYGHGLYW 2231617-62-0 99.45%
    GHGVYGHGVYGHGPYGHGPYGHGLYW (DgHBP-2) is 26-amino-acid-long consensus peptide derived from histidine-rich beak protein-2 (DgHBP-2). GHGVYGHGVYGHGPYGHGPYGHGLYW can be used fabricated glucose-responsive insulin delivery system.
    GHGVYGHGVYGHGPYGHGPYGHGLYW
  • HY-P11055
    IKFQFHFD 2169935-95-7
    IKFQFHFD is a pH-responsive and self-assembling peptide. IKFQFHFD is biocompatible at neutral pH and becomes an antimicrobial peptide-like molecular structure only at acidic pH. IKFQFHFD can be used for chronic wounds (venous ulcers, diabetic ulcers, and pressure ulcers) induced by biofilm infections research.
    IKFQFHFD
  • HY-P10794
    LH2 peptide
    LH2 peptide is a pH-responsive cell-penetrating peptide dimer with the amino acid sequence LHHLCHLLHHLCHLAG. It can increase its uptake in tumor cells under weakly acidic conditions (such as the tumor microenvironment) through the protonation of histidine residues (pKa approximately 6). When conjugated with the anticancer drug Paclitaxel (HY-B0015), the PTX-LH2 conjugate showed superior tumor suppression effects compared to paclitaxel alone in a subcutaneous breast tumor model. The LH2 peptide holds potential as a drug delivery vehicle in cancer research.
    LH2 peptide
  • HY-P10534
    ccβ 873582-78-6
    CCβ is a simple 17-amino acid peptide designed in research. CCβ is able to mimic the conformational transition of proteins from α-helix to β-sheet, which is a key step in the aggregation of proteins associated with many diseases, such as Alzheimer's disease and prion disease. CCβ can be used to study diseases related to protein aggregation.
    ccβ