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  6. pH-Low Insertion Peptide TFA

pH-Low Insertion Peptide TFA  (Synonyms: pHLIP TFA)

Cat. No.: HY-P4116A Purity: 96.37%
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pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors.

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pH-Low Insertion Peptide TFA Chemical Structure

pH-Low Insertion Peptide TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of pH-Low Insertion Peptide TFA:

pH-Low Insertion Peptide TFA Related Antibodies

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Description

pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors[1][2][3].

In Vitro

pH-Low Insertion Peptide TFA (5 μM, 2 h) combined with peptide nucleic acid (peptide nucleic acid, PNA) significantly increases PNA delivery at pH 6.2 in A549 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

pH-Low Insertion Peptide TFA Related Antibodies

Immunofluorescence[3]

Cell Line: A549 cells
Concentration: 5 μM
Incubation Time: 2 h
Result: Significantly increases PNA delivery combined with PNA at pH 6.2 in A549 cells.
In Vivo

pH-Low Insertion Peptide TFA (50 μM, a single tail vein injection, 4, 24, and 48 h) variants shows the pH-dependent tumor targeting and different blood clearance profiles, the overall tumor spatial distributions are identical in murine 4T1 xenograft mode[2].
pH-Low Insertion Peptide TFA (10 μM, i.v., a single dose for 24 h) can clearly differentiate between regions of primarily tumor cells and nonmalignant stromal tissues, also accumulates the hypoxia marker Pimonidazole (HY-105129A) and relates to the production of acidic glucose metabolites in MMTV-Py MT mice[2].
pH-Low Insertion Peptide TFA (0.2 μmol/kg, i.v., a single dose for 24 h) demonstrats excellent tumor targeting combined with PNA in mice seeded melanoma tumors[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine 4T1 xenograft model[2]
Dosage: 50 μM
Administration: a single tail vein injection, tumors collected at 4, 24, and 48 h after administration
Result: The spatial distribution and the intensity profiles of all pHLIP TFAs in tumors were identical in murine 4T1 xenograft mode.
Animal Model: FVB/N-Tg(MMTV-PyVT)634Mul/J transgenic female mice developed palpable mammary tumors at 12-15 weeks of age[2]
Dosage: 10 μM
Administration: i.v., a single dose for 24 h
Result: Clearly differentiated between regions of primarily tumor cells and nonmalignant stromal tissues.
Animal Model: 6-week old C57BL/6 mice seeded melanoma tumors[3]
Dosage: 0.2 μmol/kg
Administration: intravenously injected via the retro-orbital sinus, a single dose for 24 h
Result: All the pH-Low Insertion Peptide TFA-PNAs demonstrated excellent tumor targeting.
Molecular Weight

4054.57 (free base)

Formula

C189H282N42O55S.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ala-Cys-Glu-Gln-Asn-Pro-Ile-Tyr-Trp-Ala-Arg-Tyr-Ala-Asp-Trp-Leu-Phe-Thr-Thr-Pro-Leu-Leu-Leu-Leu-Asp-Leu-Ala-Leu-Leu-Val-Asp-Ala-Asp-Glu-Thr
Sequence Shortening

ACEQNPIYWARYADWLFTTPLLLLDLALLVDADET
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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pH-Low Insertion Peptide TFA Related Classifications

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The dilution calculator equation

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pH-Low Insertion PeptidepHLIPOtherspH-responsive peptideacidic tumor microenvironmentspecific ligandcancerdeliverInhibitorinhibitorinhibit

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