2. Apoptosis Anti-infection
  3. Apoptosis HSV
  4. Perillic acid

Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities.

For research use only. We do not sell to patients.

Perillic acid Chemical Structure

Perillic acid Chemical Structure

CAS No. : 7694-45-3

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Other Forms of Perillic acid:

Perillic acid Related Antibodies

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Description

Perillic acid is the metabolite of Perillyl alcohol (HY-N7000). Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities[1][2][3].

IC50 & Target[2]

HSV-1

 

In Vitro

Perillic acid (1-5 mM; 24 h) decreases A549 cells survival in a dose-dependent manner[1].
Perillic acid (1 mM; 24 h) induces S-phase arrest in A549 cells and induces G2/M arrest in H520 cells[1].
Perillic acid (2 mM; 24 h) induces A549 and H520 cells apoptosis[1].
Perillic acid (0-50 μM; 24 h) shows potential antiviral activity primarily against the 17syn+ HSV-1 strain (EC50 KOS: 2.84 μM; 17syn+: 1.08 μM)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Perillic acid Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549 cells
Concentration: 1, 2, 3, 4 and 5 mM
Incubation Time: 24 h
Result: Resulted in decreased survival in a dose-dependent manner with an IC50 of 3.6 mM.

Cell Cycle Analysis[1]

Cell Line: A549 and H520 cells
Concentration: 1 mM
Incubation Time: 24 h
Result: Induced S-phase arrest in A549 cells and induced G2/M arrest in H520 cells.

Apoptosis Analysis[1]

Cell Line: A549 and H520 cells
Concentration: 2 mM
Incubation Time: 24 h
Result: Increased apoptosis to 27% in A549 and to 18% in H520 cells compared to control (12%).

Western Blot Analysis[1]

Cell Line: H520 cells
Concentration: 0.5 mM
Incubation Time: 24 h
Result: Increased Bax expression and decreased procaspase-3 levels.
In Vivo

Perillic acid (50 μM/kg; i.p.; daily for 5 days) shows immunomodulatory activity in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[3]
Dosage: 50 μM/kg
Administration: Intraperitoneal injection, daily for 5 days
Result: Increased the total white blood cells (WBC) count. Increased the total antibody production, antibody producing cells in spleen, bone marrow cellularity and α-esterase positive cells significantly compared to the normal animals.
Molecular Weight

166.22

Formula

C10H14O2
CAS No.
SMILES

O=C(C1=CCC(C(C)=C)CC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Perillic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perillic acid7694-45-3ApoptosisHSVHerpes simplex virusnon small cell lung cancerNSCLCA549H520Baxprocaspase-3Inhibitorinhibitorinhibit

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