2. Cell Cycle/DNA Damage Apoptosis
  3. PERK Apoptosis
  4. PERK/eIF2α activator 1

PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM.

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PERK/eIF2α activator 1 Chemical Structure

PERK/eIF2α activator 1 Chemical Structure

CAS No. : 1178583-17-9

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PERK/eIF2α activator 1 Related Antibodies

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Description

PERK/eIF2α activator 1 (compound V8) is a flavonoid with an anti-tumor activity. PERK/eIF2α activator 1 induces apoptosis and activates the PERK-eIF2α-ATF4 pathway. PERK/eIF2α activator 1 inhibits HepG2 cell proliferation with an IC50 value of 23 μM[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.26 μM
Compound: 3b
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
HepG2 IC50
2.64 μM
Compound: 3b
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28117202]
Molecular Weight

443.49

Formula

C24H29NO7
CAS No.
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCCCCN(CCO)CCO)=CC(O)=C13)OC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PERK/eIF2α activator 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PERK/eIF2α activator 11178583-17-9PERKApoptosisProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseFlavonoidanti-tumorInhibitorinhibitorinhibit

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