2. Anti-infection
  3. Bacterial
  4. PF-04753299

PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection.

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PF-04753299 Chemical Structure

PF-04753299 Chemical Structure

CAS No. : 1289620-49-0

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1 mg USD 130 In-stock
5 mg USD 320 In-stock
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Description

PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection[1].

IC50 & Target

IC50: bacterial[1]
Molecular Weight

347.43

Formula

C18H21NO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NO)[C@@](S(=O)(C)=O)(C)CCC1=CC=C(C2=CC=CC=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (57.57 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8783 mL 14.3914 mL 28.7828 mL
5 mM 0.5757 mL 2.8783 mL 5.7566 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

COA (247 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8783 mL 14.3914 mL 28.7828 mL 71.9569 mL
5 mM 0.5757 mL 2.8783 mL 5.7566 mL 14.3914 mL
10 mM 0.2878 mL 1.4391 mL 2.8783 mL 7.1957 mL
15 mM 0.1919 mL 0.9594 mL 1.9189 mL 4.7971 mL
20 mM 0.1439 mL 0.7196 mL 1.4391 mL 3.5978 mL
25 mM 0.1151 mL 0.5757 mL 1.1513 mL 2.8783 mL
30 mM 0.0959 mL 0.4797 mL 0.9594 mL 2.3986 mL
40 mM 0.0720 mL 0.3598 mL 0.7196 mL 1.7989 mL
50 mM 0.0576 mL 0.2878 mL 0.5757 mL 1.4391 mL
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PF-04753299 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-047532991289620-49-0PF04753299PF 04753299BacterialLpxCK. pneumoniae E. coliP. aeruginosainfectionMDRgonococcalInhibitorinhibitorinhibit

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