PF-06455943

Cat. No.: HY-148353: FAQs
Data Sheet Handling Instructions

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PF-06455943 is a leucine rich repeat kinase 2 (LRRK2) inhibitor with IC₅₀ value of 3 nM. PF-06455943 also is a PET radioligand. PF-06455943 can be used for the research of ADME/neuro PK characterization and Parkinson disease (PD).

For research use only. We do not sell to patients.

PF-06455943 Chemical Structure

CAS No. : 1527474-15-2

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	20 nM Compound: 22	Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELISA method Inhibition of full length LRRK2 (unknown origin) expressed in HEK293 cells assessed as reduction in S935 phosphorylation incubated for 90 mins by ELISA method	[PMID: 25353650]

In Vitro

PF-06455943 (Compound 22) has inhibition activity for LRRK2 with IC₅₀ values of 3 nM (WT), 9 nM (G2019S) and 20 nM (cellular WCA), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

323.32

Formula

C₁₇H₁₄FN₅O

CAS No.

1527474-15-2

SMILES

N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhen Chen, et al. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. [Content Brief]

[2]. Jaclyn L Henderson, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. [Content Brief]

PF-06455943 Related Classifications

Neurological Disease

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-064559431527474-15-2PF06455943PF 06455943LRRK2Leucine-rich repeat kinase 2leucine rich repeat kinase 2 (LRRK2)Parkinson disease (PD)receptor-interacting protein (RIP)Inhibitorinhibitorinhibit

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