2. Epigenetics
  3. Epigenetic Reader Domain
  4. PF-CBP1

PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (PF-CBP1 hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

PF-CBP1 Chemical Structure

PF-CBP1 Chemical Structure

CAS No. : 1962928-21-7

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PF-CBP1 Related Antibodies

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Description

PF-CBP1 is a highly selective inhibitor of the CREB binding protein bromodomain[1].

In Vitro

PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 downregulates RGS4 in neurons, a target linked to Parkinson's disease. PF-CBP1 is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. F-CBP1 is also a potent inhibitor of EP300 (a result observed for other CBP inhibitors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-CBP1 Related Antibodies
Molecular Weight

488.62

Formula

C29H36N4O3
CAS No.
SMILES

CCCOC1=CC=C(CCC2=NC3=CC(C4=C(C)ON=C4C)=CC=C3N2CCN5CCOCC5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-CBP1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-CBP11962928-21-7Epigenetic Reader DomainInhibitorinhibitorinhibit

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