2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Phenylacetic acid mustard

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity.

For research use only. We do not sell to patients.

Phenylacetic acid mustard Chemical Structure

Phenylacetic acid mustard Chemical Structure

CAS No. : 10477-72-2

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Phenylacetic acid mustard Related Antibodies

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Description

Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity[1].

IC50 & Target

IC50: metabolite of Chlorambucil[1]
In Vivo

Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; 15 days) shows consistently 1.8-1.9 times greater antitumour potency than CHL, it exhibits an ED15 value of 8.0 mg/kg[2].
Phenylacetic acid mustard (intraperitoneal injection; 0-20 mg/kg; single dose) cause 50% lethality at the dose 15.9 mg/kg[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Inbred male C3H/He mice[1]
Dosage: 0 mg/kg; 5 mg/kg; 10 mg/kg; 20 mg/kg
Administration: Intraperitoneal injection; 15 days
Result: Exhibited anti-tumor activities in vivo.
Molecular Weight

276.16

Formula

C12H15Cl2NO2
CAS No.
SMILES

O=C(O)CC1=CC=C(N(CCCl)CCCl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    Phenylacetic acid mustard (PAAM) is dissolved in acidified ethanol (4.8 ml cone HC1 and 95% v/v ethyl alcohol in a volume of 100 ml) and diluted 1:9 with propylene glycol/K2HPO 4 buffer (20 g K2HPO4 plus 450 ml propylene glycol), final pH 7.4[2].

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
Purity & Documentation
References
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Phenylacetic acid mustard Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylacetic acid mustard10477-72-2DNA Alkylator/CrosslinkerchemotherapeuticagentmetaboliteantitumorInhibitorinhibitorinhibit

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Phenylacetic acid mustard
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HY-136327
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