Phenylhydroquinone (Synonyms: 2-Phenylhydroquinone)

Cat. No.: HY-W016181: FAQs
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Phenylhydroquinone (PHQ) is an orally active thymic atrophy inducer which can up-regulate apoptosis through activation of p53. PHQ can be used for research of thymic atrophy.

For research use only. We do not sell to patients.

Phenylhydroquinone Chemical Structure

CAS No. : 1079-21-6

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ERK ERK1 ERK2 ERK5 ERK8

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

Biological Activity
Purity & Documentation
References
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Description

Phenylhydroquinone (PHQ) is an orally active thymic atrophy inducer which can up-regulate apoptosis through activation of p53. PHQ can be used for research of thymic atrophy^[1].

IC₅₀ & Target

ERK1

ERK2

In Vitro

Phenylhydroquinone (10 μM, 3 h) activates p53 through phosphorylation of Erk1/2 and p38 but not through ATR phosphorylation in mouse thymocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

186.21

Formula

C₁₂H₁₀O₂

CAS No.

1079-21-6

SMILES

OC1=CC(C2=CC=CC=C2)=C(O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nakata Y, et al. Phenylhydroquinone induces loss of thymocytes through cell cycle arrest and apoptosis elevation in p53-dependent pathway. J Toxicol Sci. 2013;38(3):325-35. [Content Brief]

Phenylhydroquinone Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phenylhydroquinone1079-21-62-PhenylhydroquinoneMDM-2/p53ERKp38 MAPKExtracellular signal regulated kinasesthymic atrophyp53apoptosisERK1/2p38Inhibitorinhibitorinhibit

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