Philanthotoxin 74 diTFA (Synonyms: PhTx 74 diTFA)

Cat. No.: HY-104020B: FAQs
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Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC₅₀s of 263 and 296 nM, respectively.

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Philanthotoxin 74 diTFA Chemical Structure

CAS No. : 401601-12-5

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Other In-stock Forms of Philanthotoxin 74 diTFA:

Philanthotoxin 74 dihydrochloride

Other Forms of Philanthotoxin 74 diTFA:

Philanthotoxin 74 dihydrochloride In-stock

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AMPA Receptor NMDA Receptor Kainate Receptor

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Description	Philanthotoxin 74 (PhTx 74) diTFA is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC₅₀s of 263 and 296 nM, respectively^[1]^[2].
IC₅₀ & Target	IC50: 296 nM (GluR1), 293 nM (GluR3)^[1] Ki: 0.29 μM (GluR5Q)^[2]
Molecular Weight	662.66
Formula	C₂₈H₄₄F₆N₄O₇
CAS No.	401601-12-5
SMILES	O=C(NCCCCCCCNCCCCN)[C@@H](NC(CCC)=O)CC1=CC=C(O)C=C1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Poulsen MH, et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8. [Content Brief] [2]. Kromann H, et al. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors. J Med Chem. 2002 Dec 19;45(26):5745-54. [Content Brief]

Philanthotoxin 74 diTFA Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Philanthotoxin 74 diTFA401601-12-5PhTx 74 diTFAiGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Philanthotoxin 74 diTFA (Synonyms: PhTx 74 diTFA)

Other Forms of Philanthotoxin 74 diTFA:

Philanthotoxin 74 diTFA Related Antibodies

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