Phomoxanthone A

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Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively.

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Phomoxanthone A Chemical Structure

CAS No. : 359844-69-2

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.58 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	0.75 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.01 μM Compound: PXA	Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780	IC₅₀	1.44 μM Compound: PXA	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	0.86 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.18 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.25 μM Compound: PXA	Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human A2780cisR cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
A2780cisR	IC₅₀	1.37 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
A2780cisR	IC₅₀	1.88 μM Compound: PXA	Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human A2780cisR cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31443950]
BC1 cell line	IC₅₀	0.51 μg/mL Compound: 1	Cytotoxicity against human BC1 cells by SRB assay Cytotoxicity against human BC1 cells by SRB assay	[PMID: 11520217]
CAL-27	IC₅₀	5.25 μM Compound: PXA	Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human CAL27 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
HCT-116	IC₅₀	1.82 μM Compound: PXA	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.04 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	2.75 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.12 μM Compound: PXA	Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in cisplatin resistant human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.23 μM Compound: PXA	Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human J82 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
J82	IC₅₀	3.34 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 2 hrs by TMRE staining based flow cytometry	[PMID: 31443950]
J82	IC₅₀	3.75 μM Compound: PXA	Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry Induction of apoptosis in human J82 cells assessed as depolarization of mitochondrial membrane potential incubated for 1 hr by TMRE staining based flow cytometry	[PMID: 31443950]
K562	IC₅₀	1.86 μM Compound: PXA	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KB	IC₅₀	0.99 μg/mL Compound: 1	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 11520217]
KYSE-510	IC₅₀	0.76 μM Compound: PXA	Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
KYSE-510	IC₅₀	0.79 μM Compound: PXA	Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human cisplatin resistant KYSE-510 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	3.7 μM Compound: PXA	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
MDA-MB-231	IC₅₀	4.37 μM Compound: PXA	Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against cisplatin-resistant human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31443950]
Vero	IC₅₀	1.4 μg/mL Compound: 1	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 11520217]

Molecular Weight

750.70

Formula

C₃₈H₃₈O₁₆

CAS No.

359844-69-2

SMILES

O=C1C2=C(O[C@@]3(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C31)C(C4=CC=C(O)C5=C4O[C@@]6(COC(C)=O)[C@@H](OC(C)=O)[C@@H](C)CC(O)=C6C5=O)=CC=C2O

Structure Classification

Initial Source

Microorganisms

Endophytic Fungus Phomopsis Species

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Isaka M, et al., Phomoxanthones A and B, novel xanthone dimers from the endophytic fungus Phomopsis species. J Nat Prod. 2001 Aug;64(8):1015-8. [Content Brief]

Phomoxanthone A Related Classifications

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phomoxanthone A359844-69-2ParasiteAntimalarialantitubercularPlasmodium falciparumMycobacterium tuberculosisK1H37RaKBBC-1VeroInhibitorinhibitorinhibit

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