2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Phosphodiesterase-IN-2

Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models.

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Phosphodiesterase-IN-2 Chemical Structure

Phosphodiesterase-IN-2 Chemical Structure

CAS No. : 3047610-96-5

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Phosphodiesterase-IN-2 Related Antibodies

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Description

Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline (HY-108353)-induced cardiac hypertrophic in mouse models[1].

IC50 & Target

PDE10A

11.9 nM (IC50)

Molecular Weight

584.59

Formula

C32H27F3N6O2
CAS No.
SMILES

FC(F)(F)C(C=C1C2=CC(C)=NC=C2)=NN1C3=CC=C(OCC4=NC5=C(C=CC=C5)C(C(N6CC7(CNC7)C6)=O)=C4)C=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phosphodiesterase-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phosphodiesterase-IN-23047610-96-5Phosphodiesterase (PDE)C57BL6/J mousecardiac hypertrophicselectiveorally activeInhibitorinhibitorinhibit

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