Phthalimidinoglutarimide-5-piperazine

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Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

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Phthalimidinoglutarimide-5-piperazine Chemical Structure

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Other Forms of Phthalimidinoglutarimide-5-piperazine:

Lenalidomide 5'-piperazine Get quote

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•Related Small Molecules:

•Related Proteins:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description	Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
IC₅₀ & Target	Cereblon (CRBN)^[1]
Molecular Weight	328.37
Formula	C₁₇H₂₀N₄O₃
SMILES	O=C1NC(CCC1N2C(C3=C(C=C(C=C3)N4CCNCC4)C2)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief] [2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. [Content Brief] [3]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [Content Brief]