2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Phthalimidinoglutarimide-5-piperazine

Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

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Phthalimidinoglutarimide-5-piperazine Chemical Structure

Phthalimidinoglutarimide-5-piperazine Chemical Structure

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Other In-stock Forms of Phthalimidinoglutarimide-5-piperazine:

Other Forms of Phthalimidinoglutarimide-5-piperazine:

Phthalimidinoglutarimide-5-piperazine Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]
Molecular Weight

328.37

Formula

C17H20N4O3
SMILES

O=C1NC(CCC1N2C(C3=C(C=C(C=C3)N4CCNCC4)C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phthalimidinoglutarimide-5-piperazine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phthalimidinoglutarimide-5-piperazineE3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Product Name:
Phthalimidinoglutarimide-5-piperazine
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HY-163233
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