2. PROTAC
  3. Ligands for E3 Ligase
  4. Lenalidomide 5'-piperazine

Lenalidomide 5'-piperazine is a functionalized cerebellar ligand for PROTAC development that binds an E3 ligand to terminal piperazine for subsequent chemical reactions to produce a protein deactivator with a rigid linker.

For research use only. We do not sell to patients.

Lenalidomide 5'-piperazine Chemical Structure

Lenalidomide 5'-piperazine Chemical Structure

CAS No. : 2222120-31-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Lenalidomide 5'-piperazine:

Lenalidomide 5'-piperazine Related Antibodies

Top Publications Citing Use of Products

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Description

Lenalidomide 5'-piperazine is a functionalized cerebellar ligand for PROTAC development that binds an E3 ligand to terminal piperazine for subsequent chemical reactions to produce a protein deactivator with a rigid linker[1].

Molecular Weight

364.83

Formula

C17H21ClN4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCNCC4)C=C3C2)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (274.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7410 mL 13.7050 mL 27.4100 mL
5 mM 0.5482 mL 2.7410 mL 5.4820 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.92%

SDS (393 KB)

COA (248 KB) HNMR (117 KB) RP-HPLC (232 KB) MS (74 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7410 mL 13.7050 mL 27.4100 mL 68.5251 mL
5 mM 0.5482 mL 2.7410 mL 5.4820 mL 13.7050 mL
10 mM 0.2741 mL 1.3705 mL 2.7410 mL 6.8525 mL
15 mM 0.1827 mL 0.9137 mL 1.8273 mL 4.5683 mL
20 mM 0.1371 mL 0.6853 mL 1.3705 mL 3.4263 mL
25 mM 0.1096 mL 0.5482 mL 1.0964 mL 2.7410 mL
30 mM 0.0914 mL 0.4568 mL 0.9137 mL 2.2842 mL
40 mM 0.0685 mL 0.3426 mL 0.6853 mL 1.7131 mL
50 mM 0.0548 mL 0.2741 mL 0.5482 mL 1.3705 mL
60 mM 0.0457 mL 0.2284 mL 0.4568 mL 1.1421 mL
80 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8566 mL
100 mM 0.0274 mL 0.1371 mL 0.2741 mL 0.6853 mL
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Lenalidomide 5'-piperazine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide 5'-piperazine2222120-31-0Ligands for E3 LigaseE3 ligase-recruiting MoietyPROTACCerebellar ligandInhibitorinhibitorinhibit

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