2. PI3K/Akt/mTOR
  3. PI3K Akt
  4. PI3Kα-IN-23

PI3Kα-IN-23 (Compound 9) is an inhibitor of PI3Ka H1047R.

For research use only. We do not sell to patients.

PI3Kα-IN-23 Chemical Structure

PI3Kα-IN-23 Chemical Structure

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PI3Kα-IN-23 Related Antibodies

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  • Biological Activity

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Description

PI3Kα-IN-23 (Compound 9) is an inhibitor of PI3Ka H1047R[1].

IC50 & Target[1]

PI3Kα-H1047R

 

In Vitro

PI3Kα-IN-23 inhibits pAKT phosphorylation in cell with IC50=1 nM-500 nM (T-47D); >15 μΜ (SKBR3) ,respectively[1].
PI3Kα-IN-23 can inhibit cell proliferation with EC50=500 nM-2 μΜ (T-47D); 2 μΜ-15 μΜ (SKBR3)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PI3Kα-IN-23 Related Antibodies
In Vivo


Pharmacokinetic Analysis in PK-Mouse[1]

Route Dose (mg/kg) Cl (mL/min/kg) AUClast (h·ng/mL) F (%)
i.v. 1 35.7 464 /
p.o. 10 / 1950 41

IV Vehicle: 20% PEG400 / 20% PG / 60% of 20% ΗΡβCD solution in water
PO Vehicle: 30% SBE3CD in water

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

453.53

Formula

C28H27N3O3
SMILES

CC1=CC2=C(N=C(C3CC4=C(C=CC=C4)C3)N(C)C2=O)C(C(C)NC5=CC=CC=C5C(O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3Kα-IN-23 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kα-IN-23PI3KAktPhosphoinositide 3-kinasePKBProtein kinase BcancerPK-MouseInhibitorinhibitorinhibit

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HY-163501
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