2. PI3K/Akt/mTOR
  3. PI3K
  4. PI3Kδ-IN-3

PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties.

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PI3Kδ-IN-3 Chemical Structure

PI3Kδ-IN-3 Chemical Structure

CAS No. : 1431540-99-6

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Based on 1 publication(s) in Google Scholar

PI3Kδ-IN-3 Related Antibodies

Top Publications Citing Use of Products

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Description

PI3Kδ-IN-3 (Compound 11) is a PI3Kδ inhibitor (IC50: 9 nM). PI3Kδ-IN-3 inhibits B cell function. PI3Kδ-IN-3 has good pharmacokinetic properties[1].

IC50 & Target

9 nM, 0.262 μM, 1.65 μM, 4.63 μM (PI3Kδ, PI3Kα, PI3Kβ, PI3Kγ)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 30 μM
Compound: 11
Displacement of [3H]dofetilide from recombinant human ERG transfected in HEK293 cell membranes after 60 mins by scintillation counting
Displacement of [3H]dofetilide from recombinant human ERG transfected in HEK293 cell membranes after 60 mins by scintillation counting
[PMID: 27563400]
Molecular Weight

492.53

Formula

C28H24N6O3
CAS No.
SMILES

N#CC1=CC(C2=CC3=C(C4=CC=CC(C(N5CCN(C(C)=O)CC5)=O)=C4)N=CN=C3C=C2)=CN=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI3Kδ-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI3Kδ-IN-31431540-99-6PI3KPhosphoinositide 3-kinaseB cellPI3Kδ inhibitionimmuneB cell inhibitionInhibitorinhibitorinhibit

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