Pildralazine  (Synonyms: Propyldazine)

Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model^[1][2].

Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay^[1].
Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats^[2].
Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

197.24

C₈H₁₅N₅O

64000-73-3

CC(O)CN(C(C=C/1)=NNC1=N\N)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Della Porta G, Dragani TA. Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound. J Cancer Res Clin Oncol. 1983;106(2):97-101.  [Content Brief]

  [2]. Chevillard C, et al. Interactions between hydralazine, propildazine and purines on arterial smooth muscle. Br J Pharmacol. 1981 Aug;73(4):811-7.   [Content Brief]

  [3]. Dorigotti L, et al. Effects of pildralazine alone and in combination on severe hypertension and cerebrovascular lesions in saline-drinking spontaneously hypertensive rats. Arzneimittelforschung. 1984;34(8):876-9.  [Content Brief]