Pimodivir hydrochlorid hemihydrate  (Synonyms: VX-787 hydrochlorid hemihydrate)

Pimodivir hydrochlorid hemihydrate (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit.

444.87

C₂₀H₁₉F₂N₅O₂.HCl.1/2H₂O

1777721-70-6

FC1=CN=C2NC=C(C3=NC=C(F)C(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=N3)C2=C1.Cl.O.[0.5]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Smee DF, et al. Activities of JNJ63623872 and GS 4071 against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Res. 2016 Dec;136:45-50.  [Content Brief]

  [2]. Fu Y, et al. JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses. Antiviral Res. 2016 Sep;133:23-31.  [Content Brief]

  [3]. Boyd MJ, et al. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1;25(9):1990-4.  [Content Brief]

  [4]. Byrn RA, et al. Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit. Antimicrob Agents Chemother. 2015 Mar;59(3):1569-82.  [Content Brief]