Pip6a 

Pip6a is an arginine-rich cell-penetrating peptide. Pip6a has the ability to deliver associated cargoes across the plasma and endosomal membranes and is stable to serum proteolysis. Pip6a is composed of a hydrophobic core region flanked on each side by arginine-rich domains containing β-alanine and aminohexanoyl spacers. Pip6a-conjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced antisense oligonucleotide (ASO) delivery into striated muscles of myotonic dystrophy (DM1) mice^[1].

2952.56

C₁₃₀H₂₃₁N₅₃O₂₆

Ac-Arg-{Ahx}-Arg-Arg-{b-Ala}-Arg-Arg-{Ahx}-Arg-Tyr-Gln-Phe-Leu-Ile-Arg-{Ahx}-Arg-{b-Ala}-Arg-{Ahx}-Arg-{b-Ala}

Ac-R-{Ahx}-RR-{b-Ala}-RR-{Ahx}-RYQFLIR-{Ahx}-R-{b-Ala}-R-{Ahx}-R-{b-Ala}

NC(NCCC[C@@H](C(N[C@H](C(NCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCC(N[C@H](C(NCCCCCC(N[C@H](C(NCCC(O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC(C)C)=O)CC1=CC=CC=C1)=O)CCC(N)=O)=O)CC2=CC=C(O)C=C2)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)NC(CCCCCNC([C@H](CCCNC(N)=N)NC(C)=O)=O)=O)=N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Arnaud F Klein, et al. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice. J Clin Invest. 2019 Nov 1;129(11):4739-4744.  [Content Brief]