Pipecolic acid-d₉

Cat. No.: HY-Y0669S Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Pipecolic acid-d₉ is the deuterium labeled Pipecolic acid. Pipecolic acid is a metabolite of lysine and an important precursor for many useful microbial secondary metabolites. Pipecolic acid slows ferroptosis in diabetic retinopathy by inhibiting the YAP-GPX4 signaling pathway. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxine-dependent epilepsy.

For research use only. We do not sell to patients.

Pipecolic acid-d<sub>9</sub> Chemical Structure

Pipecolic acid-d₉ Chemical Structure

CAS No. : 790612-94-1

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Other Forms of Pipecolic acid-d₉:

Pipecolic acid In-stock

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

138.21

Formula

C₆H₂D₉NO₂

CAS No.

790612-94-1

Unlabeled CAS

535-75-1

Appearance

Solid

Color

White to off-white

SMILES

OC(C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])N1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (361.77 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.2354 mL	36.1768 mL	72.3537 mL
5 mM	1.4471 mL	7.2354 mL	14.4707 mL
10 mM	0.7235 mL	3.6177 mL	7.2354 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. He M, et al. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7. [Content Brief]

[3]. Plecko B, et, al. Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. Neuropediatrics. 2005 Jun;36(3):200-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	7.2354 mL	36.1768 mL	72.3537 mL	180.8842 mL
	5 mM	1.4471 mL	7.2354 mL	14.4707 mL	36.1768 mL
	10 mM	0.7235 mL	3.6177 mL	7.2354 mL	18.0884 mL
	15 mM	0.4824 mL	2.4118 mL	4.8236 mL	12.0589 mL
	20 mM	0.3618 mL	1.8088 mL	3.6177 mL	9.0442 mL
	25 mM	0.2894 mL	1.4471 mL	2.8941 mL	7.2354 mL
	30 mM	0.2412 mL	1.2059 mL	2.4118 mL	6.0295 mL
	40 mM	0.1809 mL	0.9044 mL	1.8088 mL	4.5221 mL
	50 mM	0.1447 mL	0.7235 mL	1.4471 mL	3.6177 mL
	60 mM	0.1206 mL	0.6029 mL	1.2059 mL	3.0147 mL
	80 mM	0.0904 mL	0.4522 mL	0.9044 mL	2.2611 mL
	100 mM	0.0724 mL	0.3618 mL	0.7235 mL	1.8088 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.