2. Metabolic Enzyme/Protease Stem Cell/Wnt Apoptosis Immunology/Inflammation NF-κB
  3. Endogenous Metabolite YAP Glutathione Peroxidase Ferroptosis Apoptosis Reactive Oxygen Species
  4. Pipecolic acid

Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy.

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Pipecolic acid Chemical Structure

Pipecolic acid Chemical Structure

CAS No. : 535-75-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 2 publication(s) in Google Scholar

Other Forms of Pipecolic acid:

Pipecolic acid Related Antibodies

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Description

Pipecolic acid is a metabolite of lysine and an immunomodulator, which can induce systemic acquired resistance (SAR) in plants. Pipecolic acid inhibits ferroptosis in diabetic retinopathy through the YAP-GPX4 signaling pathway. Pipecolic acid can induce apoptosis in neuronal cells. In addition, Pipecolic acid can be used as a diagnostic marker for pyridoxin-dependent epilepsy[1][2][3][4][5].

In Vitro

Pipecolic acid (1-2000 μM; 6-48 h) can induce systemic acquired resistance by increasing the levels of free radicals, NO and ROS[1].
Pipecolic acid can inhibit oxidative stress, ferroptosis and apoptosis in HRCECs cells treated with high glucose, which is related to GPX4-YAP signaling pathway[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pipecolic acid Related Antibodies
In Vivo

Pipecolic acid (intragastric administration; 250 mg/kg; 1 week) can improve diabetic retinopathy in mouse model[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male wild-type C57BL/6 mice aged 8 weeks old with Diabetic retinopathy (DR)[3]
Dosage: 250 mg/kg
Administration: Intragastric administration; 1 week
Result: Had positive effects on weight gain and blood sugar level in mice.
Significantly reduced the ratio of retinal positive areas to whole positive areas.
Regulated oxidative stress and iron metabolism.
Molecular Weight

129.16

Formula

C6H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1CCCCN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (387.12 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.7423 mL 38.7117 mL 77.4233 mL
5 mM 1.5485 mL 7.7423 mL 15.4847 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.7423 mL 38.7117 mL 77.4233 mL 193.5584 mL
5 mM 1.5485 mL 7.7423 mL 15.4847 mL 38.7117 mL
10 mM 0.7742 mL 3.8712 mL 7.7423 mL 19.3558 mL
15 mM 0.5162 mL 2.5808 mL 5.1616 mL 12.9039 mL
20 mM 0.3871 mL 1.9356 mL 3.8712 mL 9.6779 mL
25 mM 0.3097 mL 1.5485 mL 3.0969 mL 7.7423 mL
30 mM 0.2581 mL 1.2904 mL 2.5808 mL 6.4519 mL
40 mM 0.1936 mL 0.9678 mL 1.9356 mL 4.8390 mL
50 mM 0.1548 mL 0.7742 mL 1.5485 mL 3.8712 mL
60 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2260 mL
80 mM 0.0968 mL 0.4839 mL 0.9678 mL 2.4195 mL
100 mM 0.0774 mL 0.3871 mL 0.7742 mL 1.9356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pipecolic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipecolic acid535-75-1Endogenous MetaboliteYAPGlutathione PeroxidaseFerroptosisApoptosisReactive Oxygen SpeciesYes-associated proteinDiabetic retinopathy modelneuronal cellsHRCECsInhibitorinhibitorinhibit

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