Piperacillin hydrate  (Synonyms: Pipracil hydrate)

Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin hydrate is most commonly used in combination with the β-lactamase inhibitor Tazobactam (HY-B1418)^[1][2][3].

Piperacillin (12.5 μg/mL, 24h) hydrate inhibits 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella spp, and 42% of Enterobacter spp, most Proteus spp. are extremely susceptible. Piperacillin hydrate fails to inhibit the growth of gram-negative bacilli when large inocula were used (minimum inhibitory concentration >25 μg/mL) ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Piperacillin (100 mg/kg, i.v., 4 times a day, 5 d) hydrate in combination with Tazobactam (HY-B1418)(12.5 mg/kg, i.v., 4 times a day, 5 d) prolongs survival in mice with low inoculum of K. pneumoniae^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

535.57

C₂₃H₂₉N₅O₈S

66258-76-2

O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC([C@H](NC(N3C(C(N(CC)CC3)=O)=O)=O)C4=CC=CC=C4)=O)N1C2=O)O.O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fu KP, et al. Piperacillin, a new penicillin active against many bacteria resistant to other penicillins. Antimicrob Agents Chemother. 1978, 13(3):358-67.  [Content Brief]

  [2]. Bodey GP, et al. Piperacillin: In Vitro Evaluation. Antimicrob Agents Chemother. 1978, 14(1):78-87.  [Content Brief]

  [3]. Harada Y, et al. In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae. Clin Microbiol Infect. 2014, 20(11):O831-9.  [Content Brief]