2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. Piperidine-GNE-049-N-Boc

Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP.

For research use only. We do not sell to patients.

Piperidine-GNE-049-N-Boc Chemical Structure

Piperidine-GNE-049-N-Boc Chemical Structure

CAS No. : 1936431-36-5

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1 mg USD 328 In-stock
5 mg USD 820 In-stock
10 mg USD 1300 In-stock
25 mg USD 2650 In-stock
50 mg USD 4250 In-stock
100 mg USD 6800 In-stock
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Based on 1 publication(s) in Google Scholar

Piperidine-GNE-049-N-Boc Related Antibodies

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Description

Piperidine-GNE-049-N-Boc is a ligand for target protein for PROTAC of dCBP-1 (HY-134582). dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP[1].

In Vitro

Piperidine-GNE-049-N-Boc (S17) can be used for synthesizing dCBP-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Piperidine-GNE-049-N-Boc Related Antibodies
Molecular Weight

567.67

Formula

C30H39F2N7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCC(N(C2CCNCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

1M HCl : 32.5 mg/mL (57.25 mM; ultrasonic and adjust pH to 1 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7616 mL 8.8079 mL 17.6159 mL
5 mM 0.3523 mL 1.7616 mL 3.5232 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M HCl 1 mM 1.7616 mL 8.8079 mL 17.6159 mL 44.0397 mL
5 mM 0.3523 mL 1.7616 mL 3.5232 mL 8.8079 mL
10 mM 0.1762 mL 0.8808 mL 1.7616 mL 4.4040 mL
15 mM 0.1174 mL 0.5872 mL 1.1744 mL 2.9360 mL
20 mM 0.0881 mL 0.4404 mL 0.8808 mL 2.2020 mL
25 mM 0.0705 mL 0.3523 mL 0.7046 mL 1.7616 mL
30 mM 0.0587 mL 0.2936 mL 0.5872 mL 1.4680 mL
40 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1010 mL
50 mM 0.0352 mL 0.1762 mL 0.3523 mL 0.8808 mL
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Piperidine-GNE-049-N-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Piperidine-GNE-049-N-Boc1936431-36-5Ligands for Target Protein for PROTACTarget Protein-binding MoietyligandtargetproteinPROTACdCBP-1heterobifunctionaldegraderp300CBPInhibitorinhibitorinhibit

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Product Name:
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Cat. No.:
HY-134592
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