PKHB1 

PKHB1 is a thrombospondin-1 peptide mimic with antitumor effects. PKHB1 induces mitochondrial alterations, ROS production, intracellular Ca²⁺ accumulation, as well calcium-dependent cell death in breast cancer cells. PKHB1 induces immune system activation through immunogenic cell death induction in breast cancer cells^[1].

1384.73

C₆₈H₁₀₅N₁₇O₁₂S

1505523-99-8

{d-Lys}-Arg-Phe-Tyr-Val-Val-Met-Trp-Lys-{d-Lys}

{d-Lys}-RFYVVMWK-{d-Lys}

NCCCC[C@H](C(O)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCSC)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](N)CCCCN)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Calvillo-Rodríguez KM, et al. PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cells. Oncoimmunology. 2022 Apr 4;11(1):2054305.