2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. PKL-IN-1

PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC50 values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration.

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PKL-IN-1 Chemical Structure

PKL-IN-1 Chemical Structure

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5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1600 In-stock
50 mg USD 2600 In-stock
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Based on 1 publication(s) in Google Scholar

PKL-IN-1 Related Antibodies

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Description

PKL-IN-1 (Compound 12a) is a potent pyruvate kinase L (PKL) inhibitor with IC50 values of 0.07 μM and 0.18 μM for PKL and PKR subtypes, respectively. PKL-IN-1 can inhibit 96.6% PKL activity at 10 μM concentration[1].

IC50 & Target

IC50: 0.07 μM (PKL)[1]
Molecular Weight

312.25

Formula

C12H8O8S
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(O)C=C(C(C(O)=C(O)C(O)=C2)=C2OS3(=O)=O)C3=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (400.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2026 mL 16.0128 mL 32.0256 mL
5 mM 0.6405 mL 3.2026 mL 6.4051 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2026 mL 16.0128 mL 32.0256 mL 80.0641 mL
5 mM 0.6405 mL 3.2026 mL 6.4051 mL 16.0128 mL
10 mM 0.3203 mL 1.6013 mL 3.2026 mL 8.0064 mL
15 mM 0.2135 mL 1.0675 mL 2.1350 mL 5.3376 mL
20 mM 0.1601 mL 0.8006 mL 1.6013 mL 4.0032 mL
25 mM 0.1281 mL 0.6405 mL 1.2810 mL 3.2026 mL
30 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
40 mM 0.0801 mL 0.4003 mL 0.8006 mL 2.0016 mL
50 mM 0.0641 mL 0.3203 mL 0.6405 mL 1.6013 mL
60 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
80 mM 0.0400 mL 0.2002 mL 0.4003 mL 1.0008 mL
100 mM 0.0320 mL 0.1601 mL 0.3203 mL 0.8006 mL
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PKL-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKL-IN-1Pyruvate KinaseSulfaketoneNAFLDPyruvate kinase liverSulfone heterocyclesInhibitorinhibitorinhibit

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