2. Anti-infection
  3. Bacterial
  4. Pks13-TE inhibitor 3

Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB.

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Pks13-TE inhibitor 3 Chemical Structure

Pks13-TE inhibitor 3 Chemical Structure

CAS No. : 3031462-62-8

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Pks13-TE inhibitor 3 Related Antibodies

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Description

Pks13-TE inhibitor 3 (compound 23) is a 13-Thioesterase (Pks13-TE) inhibitor (IC50=1.55 μM). Pks13-TE inhibitor 3 shows good anti-tuberculosis activity against both agent-sensitive and drug-resistant Mtb strains (MIC=0.0625-0.25 μg/mL). Pks13-TE inhibitor 3 can be used in studies of multidrug-resistant TB and extensively drug-resistant TB[1].

IC50 & Target

IC50: 1.55 µM (Pks13-TE)[1].
In Vitro

Pks13-TE inhibitor 3 (0-5.43 µM; 7 days) demonstrates potent activities against DS (drug-susceptible Mtb strain)-tuberculosis)-TB and DR (drug-resistant strain of Mtb-tuberculosis)-TB strains with MIC range of 0.0625-0.25 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pks13-TE inhibitor 3 Related Antibodies

Cell Viability Assay[1]

Cell Line: DS (drug-susceptible Mtb strain)-tuberculosis (V4207), MDR (multidrug-resistant strain of Mtb, resistance to isoniazid and rifampin)-tuberculosis (V2475 and KZN494), XDR (extensively drug-resistant strain of Mtb resistant to isoniazid, rifampin, levofloxacin ofloxacin, and kanamycin)-tuberculosis (TF274 and R506) strains
Concentration: 0-5.43 µM (0-2048 µg/mL)
Incubation Time: 7 days
Result: Inhibited V4207/DS Mtb strain (MIC=0.125 µg/mL), V2475/MDR (MIC=0.125-0.25 µg/mL), KZN494/MDR (MIC=0.0625-0.125 µg/mL), TF274/XDR (MIC=0.0625 µg/mL) and R506/XDR (MIC=0.0625 µg/mL) Mtb strains.
Molecular Weight

383.37

Formula

C21H18FNO5
CAS No.
SMILES

O=C1C2=C(OC3=CC=C(O)C(CN4CCC(F)CC4)=C32)C5=C(O1)C=C(O)C=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pks13-TE inhibitor 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pks13-TE inhibitor 33031462-62-8BacterialM. tuberculosistuberculosisMDR-TBXDR-TBMtbbacterialInhibitorinhibitorinhibit

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