Plasmin, Human plasma  (Synonyms: Fibrinolysins, Human plasma; Serum tryptase, Human plasma; TAL 05-00018, Human plasma)

Plasmin, Human plasma is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells^[1][2].

Plasmin, Human plasma (20 μg/mL, 24 h) can activate PAR-1, strongly induce ERK phosphorylation, and degrade e-cadherin in mouse cortical tubular epithelial cell line (MCT)^[1].
Product Information
Molecular weight: ~75,4 kDa
Optimum pH: 8.5
Optimum temperature: 37°C, rapidly inactivated at 56°C

Instructions
Dissolve in water or according to the literature for the specific experiment.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

9001-90-5

Solid

White to off-white

[Plasmin, Human plasma]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Guoqiang Zhang, et al. Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals. J Am Soc Nephrol. 2007 Mar;18(3):846-59.   [Content Brief]

  [2]. Dominik F Draxler, et al. Plasmin: A Modulator of Immune Function. Semin Thromb Hemost. 2017 Mar;43(2):143-153.   [Content Brief]