2. Anti-infection
  3. Antibiotic Bacterial
  4. Plazomicin sulfate

Plazomicin sulfate  (Synonyms: ACHN 490 sulfate)

Cat. No.: HY-16955A Purity: ≥98.0%
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Handling Instructions Technical Support

Plazomicin (ACHN 490) sulfate is a potent aminoglycoside antibiotic in the fight against antimicrobial resistance. Plazomicin sulfate has in vitro activity against several multi-drug-resistant organisms, including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate has the potential to be used for multi-drug-resistant complicated urinary tract infections (cUTIs) or in combination for serious carbapenem-resistant Enterobacteriaceae infections.

For research use only. We do not sell to patients.

Plazomicin sulfate Chemical Structure

Plazomicin sulfate Chemical Structure

CAS No. : 1380078-95-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Plazomicin sulfate:

Plazomicin sulfate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Plazomicin sulfate

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Plazomicin (ACHN 490) sulfate is a potent aminoglycoside antibiotic in the fight against antimicrobial resistance. Plazomicin sulfate has in vitro activity against several multi-drug-resistant organisms, including carbapenem-resistant Enterobacteriaceae. Plazomicin sulfate has the potential to be used for multi-drug-resistant complicated urinary tract infections (cUTIs) or in combination for serious carbapenem-resistant Enterobacteriaceae infections[1].

Molecular Weight

935.94

Formula

C25H48N6O10.5/2H2SO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@](C)(O)CO1)NC)[C@@]1([H])O[C@H]2[C@@H](C[C@H](N)[C@@H](O[C@@]3([H])OC(CNCCO)=CC[C@H]3N)[C@@H]2O)NC([C@@H](O)CCN)=O.OS(O)(=O)=O.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (106.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0684 mL 5.3422 mL 10.6844 mL
5 mM 0.2137 mL 1.0684 mL 2.1369 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0684 mL 5.3422 mL 10.6844 mL 26.7111 mL
5 mM 0.2137 mL 1.0684 mL 2.1369 mL 5.3422 mL
10 mM 0.1068 mL 0.5342 mL 1.0684 mL 2.6711 mL
15 mM 0.0712 mL 0.3561 mL 0.7123 mL 1.7807 mL
20 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3356 mL
25 mM 0.0427 mL 0.2137 mL 0.4274 mL 1.0684 mL
30 mM 0.0356 mL 0.1781 mL 0.3561 mL 0.8904 mL
40 mM 0.0267 mL 0.1336 mL 0.2671 mL 0.6678 mL
50 mM 0.0214 mL 0.1068 mL 0.2137 mL 0.5342 mL
60 mM 0.0178 mL 0.0890 mL 0.1781 mL 0.4452 mL
80 mM 0.0134 mL 0.0668 mL 0.1336 mL 0.3339 mL
100 mM 0.0107 mL 0.0534 mL 0.1068 mL 0.2671 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Plazomicin sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Plazomicin1380078-95-4ACHN 490ACHN490ACHN-490AntibioticBacterialAminoglycosideantimicrobialcarbapenemEnterobacteriaceaecomplicated urinary tract infectionscUTIsInhibitorinhibitorinhibit

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