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  4. PLGA (75:25)

PLGA (75:25)  (Synonyms: poly(lactic-co-glycolic acid) (75:25))

Cat. No.: HY-B2247A Assay: 99.54%
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PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides.

For research use only. We do not sell to patients.

PLGA (75:25) Chemical Structure

PLGA (75:25) Chemical Structure

CAS No. : 34346-01-5

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Based on 1 publication(s) in Google Scholar

Other Forms of PLGA (75:25):

PLGA (75:25) Related Antibodies

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Description

PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3].

In Vitro

PLGA (75:25) (0.03-5 mg/mL; 72 h) only affects the viability of Calu-3 cells at concentrations that are too high for clinical use[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PLGA (75:25) Related Antibodies

Cell Viability Assay[1]

Cell Line: Calu-3 cells
Concentration: 0.03-5 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/CS); 3-5 mg/mL (for PLgA (75:25)/CS and PLgA (75:25)/PF68); 0.03-1 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/PF68) (CS (chitosan), PF68 and PVA (poly vinyl alcohol) serve as cationic stabilizer)
Incubation Time: 72 h
Result: Showed low toxicity to cells (cell viability was always higher than 50%) even at the highest concentration tested, when xposured to PLgA (75:25)/PVA, PLgA (75:25)/CS and PLgA (75:25)/PF68 nanoparticles.
Increased cell viability, after short exposure (4 hours) to PLGA/PF68 nanoparticles.
In Vivo

PLGA (75:25) (40 mg/kg Risperidone (PLGA (75:25) as a drug delivery carrier); s.c.; single) shows a good activity of sustained drug release for 45 days[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[2].
Dosage: 40 mg/kg (dose of Risperidone, PLGA (75:25) as a drug delivery carrier).
Administration: Subcutaneous injection; single.
Result: Achieved slow release in vivo: after an initial burst, a sharp drop occurred and the drug levels through day 22 remained in a steady manner while progressing to a decline up to day 45.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(C)OC(CO[H])=O.[x].[y]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

COA (243 KB)

Handling Instructions (2659 KB)
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PLGA (75:25) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLGA (75:25)34346-01-5poly(lactic-co-glycolic acid) (75:25)Biochemical Assay ReagentsPGAPLAPLGAslow-release drugsdrug delivery carrierpolymeric nano-compositesCalu-3Inhibitorinhibitorinhibit

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