2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. PLK1-IN-14

PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor. It has an IC50 of 22.61 pM against PLK1 and an IC50 of 0.09 nM for inhibiting the proliferation of DU - 145 prostate cancer cells. PLK1-IN-14 can be used in the research of prostate cancer.

For research use only. We do not sell to patients.

PLK1-IN-14 Chemical Structure

PLK1-IN-14 Chemical Structure

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PLK1-IN-14 Related Antibodies

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PLK1 PLK2 PLK3 PLK4

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Description

PLK1-IN-14 (Compound Hit-4) is a selective PLK1 inhibitor. It has an IC50 of 22.61 pM against PLK1 and an IC50 of 0.09 nM for inhibiting the proliferation of DU - 145 prostate cancer cells. PLK1-IN-14 can be used in the research of prostate cancer[1].

IC50 & Target

PLK1

22.61 pM (IC50)

Molecular Weight

802.92

Formula

C41H55F5N8O3
SMILES

COC1=CC(C(NC2CCC(N3CCN(C[C@H]4CCC5(CCCC5)C4)CC3)CC2)=O)=C(F)C=C1NC6=NC=C(N(C)C(C(F)(F)CN7[C@H]8CCCC8(F)F)=O)C7=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PLK1-IN-14 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLK1-IN-14Polo-like Kinase (PLK)Inhibitorinhibitorinhibit

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HY-173233
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