2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. PLK1-IN-9

PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model.

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PLK1-IN-9 Chemical Structure

PLK1-IN-9 Chemical Structure

CAS No. : 893772-67-3

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PLK1-IN-9 Related Antibodies

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Description

PLK1-IN-9 (Compound M2) is an inhibitor for polo-like kinase 1 (PLK1), that inhibits PLK proteins modified with peptides 1010pT, cdc25c and PBIP, with IC50s of 1.6, 0.8 and 1.4 μM, respectively. PLK1-IN-9 inhibits proliferations of cancer cells HeLa, HL60, SNU387/499, HepG2, exhibits cytotoxicity and induces apoptosis. PLK1-IN-9 inhibits tumor growth in HepG2 xenograft mouse model[1].

Molecular Weight

296.20

Formula

C12H7F3N4O2
CAS No.
SMILES

CN1C2=C(N=C3C1=NC(NC3=O)=O)C=C(C(F)(F)F)C=C2
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Purity & Documentation
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PLK1-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLK1-IN-9893772-67-3Polo-like Kinase (PLK)Balx/c mouseBalb/c mouseHeLaHL60U937SNU387HepG2SNU499Hep3BInhibitorinhibitorinhibit

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