(+)-Adomeglivant (Synonyms: (+)-LY2409021)

Cat. No.: HY-19904B: FAQs
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(+)-Adomeglivant ((+)-LY2409021) is a potent and selective glycogenotropin receptor antagonist with glucose-lowering activity. (+)-Adomeglivant reduces fasting blood glucose levels in both healthy subjects and patients with type 2 diabetes. The use of (+)-Adomeglivant can help investigate the mechanisms of hyperglycemia in type 2 diabetes. The antagonistic effect of (+)-Adomeglivant makes it challenging to assess the metabolic consequences of postprandial hyperglycemia.

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(+)-Adomeglivant Chemical Structure

CAS No. : 872260-19-0

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Description	(+)-Adomeglivant ((+)-LY2409021) is a potent and selective glycogenotropin receptor antagonist with glucose-lowering activity. (+)-Adomeglivant reduces fasting blood glucose levels in both healthy subjects and patients with type 2 diabetes. The use of (+)-Adomeglivant can help investigate the mechanisms of hyperglycemia in type 2 diabetes. The antagonistic effect of (+)-Adomeglivant makes it challenging to assess the metabolic consequences of postprandial hyperglycemia^[1].
Molecular Weight	555.63
Formula	C₃₂H₃₆F₃NO₄
CAS No.	872260-19-0
SMILES	O=C(O)CCNC(C1=CC=C([C@H](OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)CCC(F)(F)F)C=C1)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes [Content Brief]

(+)-Adomeglivant Related Classifications

Metabolic Disease

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(+)-Adomeglivant872260-19-0(+)-LY2409021OthersInhibitorinhibitorinhibit

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(+)-Adomeglivant (Synonyms: (+)-LY2409021)

Other Forms of (+)-Adomeglivant:

(+)-Adomeglivant Related Antibodies

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Biological Activity

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