2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. (+)-N-Allylnormetazocine hydrochloride

(+)-N-Allylnormetazocine hydrochloride  (Synonyms: (+)-SKF 10047 hydrochloride; (+)-N-Allyl-N-normetazocine hydrochloride)

Cat. No.: HY-101376 Purity: ≥99.0%
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(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease.

For research use only. We do not sell to patients.

(+)-N-Allylnormetazocine hydrochloride Chemical Structure

(+)-N-Allylnormetazocine hydrochloride Chemical Structure

CAS No. : 133005-41-1

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Based on 1 publication(s) in Google Scholar

(+)-N-Allylnormetazocine hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Opioid Receptor Isoform Specific Products:

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2].

In Vitro

(+)-N-Allylnormetazocine hydrochloride (1 nM) inhibits µ, δ and κ opioid receptors of 28.5%, 2.5% and 31%, respectively[1].
(+)-N-Allylnormetazocine hydrochloride shows Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-N-Allylnormetazocine hydrochloride Related Antibodies
In Vivo

(+)-N-Allylnormetazocine hydrochloride (0.3, 1, 3 , 10 and 30 mg/kg; intraperitoneal injection, 10 minutes before each session) dose-dependently increases the response made on the lever appropriate for dissociative anesthetics phencyclidine (PCP) in rats with PCP or saline[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

293.83

Formula

C17H24ClNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(CCN2CC=C)C3=CC(O)=CC=C3C[C@@]2([H])C1([H])C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (340.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4033 mL 17.0166 mL 34.0333 mL
5 mM 0.6807 mL 3.4033 mL 6.8067 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.4033 mL 17.0166 mL 34.0333 mL 85.0832 mL
5 mM 0.6807 mL 3.4033 mL 6.8067 mL 17.0166 mL
10 mM 0.3403 mL 1.7017 mL 3.4033 mL 8.5083 mL
15 mM 0.2269 mL 1.1344 mL 2.2689 mL 5.6722 mL
20 mM 0.1702 mL 0.8508 mL 1.7017 mL 4.2542 mL
25 mM 0.1361 mL 0.6807 mL 1.3613 mL 3.4033 mL
30 mM 0.1134 mL 0.5672 mL 1.1344 mL 2.8361 mL
40 mM 0.0851 mL 0.4254 mL 0.8508 mL 2.1271 mL
50 mM 0.0681 mL 0.3403 mL 0.6807 mL 1.7017 mL
60 mM 0.0567 mL 0.2836 mL 0.5672 mL 1.4181 mL
80 mM 0.0425 mL 0.2127 mL 0.4254 mL 1.0635 mL
100 mM 0.0340 mL 0.1702 mL 0.3403 mL 0.8508 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(+)-N-Allylnormetazocine hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-N-Allylnormetazocine133005-41-1(+)-SKF 10047(+)-N-Allyl-N-normetazocineOpioid Receptorbenzomorphan opioidneurological diseasephencyclidineratInhibitorinhibitorinhibit

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