(+)-Norfenfluramine hydrochloride

Name: (+)-Norfenfluramine hydrochloride
Brand: MedChemExpress
SKU: HY-118010A
Rating: 4.5 (1 reviews)

Cat. No.: HY-118010A Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

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(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT_2B receptor agonist (K_i: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca²⁺. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease.

For research use only. We do not sell to patients.

(+)-Norfenfluramine hydrochloride Chemical Structure

CAS No. : 37936-89-3

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 140	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (+)-Norfenfluramine hydrochloride:

(+)-Norfenfluramine In-stock

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•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT_2B Receptor

11.2 nM (Ki)

5-HT_2C Receptor

324 nM (Ki)

5-HT_2A Receptor

1516 nM (Ki)

In Vitro

(+)-Norfenfluramine (1 nM to 100 μM) hydrochloride contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats^[1].
(+)-Norfenfluramine (1 and 10 μM, 3 min) hydrochloride induces contraction in aorta from tissues of normotensive and hypertensive rats^[1].
(+)-Norfenfluramine (0-10 μM, 3 min) hydrochloride induces 5-HT release from rat hippocampal synaptosomes by Ca²⁺-dependent way ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(+)-Norfenfluramine (1-300 μg/kg, i.v.) hydrochloride induces pressor response in conscious SHAM and DOCA-salt rats^[1].
(+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) hydrochloride decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Conscious SHAM and DOCA-salt rats^[1].
Dosage:	1-300 μg/kg
Administration:	Intravenous injection (i.v.), given in a cumulative fashion at 6-min intervals.
Result:	Induced pressor response in conscious SHAM and DOCA-salt rats. (change in mean arterial blood pressure at 300 μg/kg, mm Hg, SHAM vehicle=36, SHAM ketanserin=7, DOCA=51, DOCA ketanserin=19).

Molecular Weight

239.67

Formula

C₁₀H₁₃ClF₃N

CAS No.

37936-89-3

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 18.75 mg/mL (78.23 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1724 mL	20.8620 mL	41.7240 mL
5 mM	0.8345 mL	4.1724 mL	8.3448 mL
10 mM	0.4172 mL	2.0862 mL	4.1724 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (247 KB) HNMR (253 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. [Content Brief]

[2]. M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7. [Content Brief]

[3]. R Invernizzi, et al. Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain? Br J Pharmacol. 1982 Mar;75(3):525-30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.1724 mL	20.8620 mL	41.7240 mL	104.3101 mL
	5 mM	0.8345 mL	4.1724 mL	8.3448 mL	20.8620 mL
	10 mM	0.4172 mL	2.0862 mL	4.1724 mL	10.4310 mL
	15 mM	0.2782 mL	1.3908 mL	2.7816 mL	6.9540 mL
	20 mM	0.2086 mL	1.0431 mL	2.0862 mL	5.2155 mL
	25 mM	0.1669 mL	0.8345 mL	1.6690 mL	4.1724 mL
	30 mM	0.1391 mL	0.6954 mL	1.3908 mL	3.4770 mL
	40 mM	0.1043 mL	0.5216 mL	1.0431 mL	2.6078 mL
	50 mM	0.0834 mL	0.4172 mL	0.8345 mL	2.0862 mL
	60 mM	0.0695 mL	0.3477 mL	0.6954 mL	1.7385 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.