2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. (+)-Perillyl alcohol

(+)-Perillyl alcohol  (Synonyms: (R)-(+)-Perillyl alcohol)

Cat. No.: HY-W747572
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(+)-Perillyl alcohol is the enantiomer of S-(-)-Perillyl alcohol (HY-116514). (+)-Perillyl alcohol can inhibit the growth of polypeptides and block the cell cycle in the G0/G1 phase. (+)-Perillyl alcohol induces cell signaling that is associated with changes in cytoskeletal actin organization and reduced protein expression of growth regulatory proteins such as Ras and CDC2 kinase.

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(+)-Perillyl alcohol Chemical Structure

(+)-Perillyl alcohol Chemical Structure

CAS No. : 57717-97-2

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Based on 1 publication(s) in Google Scholar

(+)-Perillyl alcohol Related Antibodies

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Description

(+)-Perillyl alcohol is the enantiomer of S-(-)-Perillyl alcohol (HY-116514). (+)-Perillyl alcohol can inhibit the growth of polypeptides and block the cell cycle in the G0/G1 phase. (+)-Perillyl alcohol induces cell signaling that is associated with changes in cytoskeletal actin organization and reduced protein expression of growth regulatory proteins such as Ras and CDC2 kinase[1].

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
78.5 μM
Compound: Perillyl alcohol
Cytotoxicity against human Caco-2 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human Caco-2 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
HepG2 IC50
100 μM
Compound: POH
Antiinvasive activity against human HepG2 cells by matrigel-based transwell assay
Antiinvasive activity against human HepG2 cells by matrigel-based transwell assay
[PMID: 30096653]
HT-29 IC50
100 μM
Compound: Perillyl alcohol
Cytotoxicity against human HT-29 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
MHCC97H IC50
100 μM
Compound: POH
Antiinvasive activity against human MHCC97H cells by matrigel-based transwell assay
Antiinvasive activity against human MHCC97H cells by matrigel-based transwell assay
[PMID: 30096653]
SMMC-7721 IC50
100 μM
Compound: POH
Antiinvasive activity against human SMMC7721 cells by matrigel-based transwell assay
Antiinvasive activity against human SMMC7721 cells by matrigel-based transwell assay
[PMID: 30096653]
T84 IC50
158 μM
Compound: Perillyl alcohol
Cytotoxicity against human T84 cells incubated upto 96 hrs by MTT assay
Cytotoxicity against human T84 cells incubated upto 96 hrs by MTT assay
[PMID: 29126728]
In Vitro

(+)-Perillyl alcohol (0.25-1 mM) inhibits cell growth in SW480 cells[1].
(+)-Perillyl alcohol (1 mM; 24 h) increases the number of G0/G1 cells and decreases the number of S phase cells in SW480 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(+)-Perillyl alcohol Related Antibodies
Molecular Weight

152.23

Formula

C10H16O
CAS No.
SMILES

CC([C@@H]1CCC(CO)=CC1)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(+)-Perillyl alcohol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Perillyl alcohol57717-97-2(R)-(+)-Perillyl alcoholRasSW480S-(-)-perillyl alcoholInhibitorinhibitorinhibit

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