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  4. Therapeutic Peptides
  5. PNC-28

PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research.

For research use only. We do not sell to patients.

PNC-28 Chemical Structure

PNC-28 Chemical Structure

CAS No. : 392661-17-5

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PNC-28 Related Antibodies

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Description

PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research[1][2].

In Vitro

PNC-28 (0-0.5 mg/mL) blocks growth of a lethal human pancreatic cancer cell line[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNC-28 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: MiaPaCa-2 human pancreatic carcinoma cells
Concentration: 0.1, 0.3, and 0.5 mg/mL
Incubation Time: daily
Result: Showed dependent induction of tumor cell death starting at 0.1 mg/ml.
In Vivo

PNC-28 (2 mg/mouse, SC or IP, for 14 days) blocks the growth of BMRPA1. Tuc3 cells in vivo[1].
PNC-28 (1-20 mg/mouse, SC, for 14 days) inhibits BMRPA1. Tuc3 tumor growth especially if delivered directly to the tumor [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 2 mg/mouse
Administration: Implanted s.c. or i.p., with 14 days mini-osmotic pumps releasing PNC-28 at a rate of 0.25 μl/hr
Result: No ascites was seen in the PNC-28-treated animals. strongly effective in inhibiting this particular tumor.
Animal Model: Athymic Nu/Nu mice (7–8 weeks, 22–24 g, injected i.p. with BMRPA1.Tuc3 cells)[1]
Dosage: 1 mg/mouse, 10 mg/mouse and 20 mg/mouse
Administration: When the tumors reached sizes from 40 to 260 mg/mouse, mini-osmotic pumps were implanted s.c. that released, over a period of 14 days
Result: Resulted in a significant level of tumor growth inhibition in a dose-related manner.
Molecular Weight

3509.13

Formula

C164H255N47O37S
CAS No.
Sequence Shortening

ETFSDLWKLLKKWKMRRNQFWVKVQRG
SMILES

[ETFSDLWKLLKKWKMRRNQFWVKVQRG]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PNC-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNC-28392661-17-5PNC28PNC 28Othersanti-tumorpancreatic cancer cellBMRPA1. TUC-3 cellsMiaPaCa-2lactate dehydrogenaseLDHascitesInhibitorinhibitorinhibit

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