PNU109291

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PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

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PNU109291 Chemical Structure

CAS No. : 187665-60-7

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Description

PNU109291 is a potent and selective 5-HT1D agonist. PNU109291 reduces dural plasma extravasation evoked by trigeminal ganglion stimulation^[1].

In Vivo

PNU109291 (0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg; s.c.) reduces dural plasma extravasation evoked by trigeminal ganglion stimulation in pigs^[1].
PNU109291 (3 µM) inhibited evoked EPSCs (excitatory postsynaptic currents) in Freund's adjuvant (CFA) but not saline-injected rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	200-500g, male Hartley guinea pigs^[1]
Dosage:	0.24, 2.4, 7.3, 24.4, 73.3 nmol/kg
Administration:	S.c.; 60 min before electrical stimulation
Result:	Dose-dependently decreased plasma protein extravasation with an IC₅₀ value of 4.2 nmol/kg.

Molecular Weight

409.52

Formula

C₂₄H₃₁N₃O₃

CAS No.

187665-60-7

SMILES

O=C(C1=CC=C2C(CCO[C@H]2CCN3CCN(C4=CC=C(OC)C=C4)CC3)=C1)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cutrer FM, et al. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology. 1999 Jul;38(7):1043-53. [Content Brief]

[2]. Winters BL, et al. Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission. Br J Pharmacol. 2020 Aug;177(16):3730-3743. [Content Brief]

PNU109291 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNU109291187665-60-7PNU 109291PNU-1092915-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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