2. Epigenetics
  3. Epigenetic Reader Domain
  4. PNZ5

PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1).

For research use only. We do not sell to patients.

PNZ5 Chemical Structure

PNZ5 Chemical Structure

CAS No. : 1629277-36-6

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Based on 1 publication(s) in Google Scholar

PNZ5 Related Antibodies

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Description

PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1, with a KD of 5.43 nM for BRD4(1)[1].

IC50 & Target[1]

BRD4(1)

5.43 nM (Kd)

Molecular Weight

318.37

Formula

C20H18N2O2
CAS No.
SMILES

CN1C(C2=CC=C(C3=C(C)ON=C3C)C=C2[C@@]1(C4=CC=CC=C4)[H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PNZ5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNZ51629277-36-6PNZ 5PNZ-5Epigenetic Reader DomainInhibitorinhibitorinhibit

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HY-100696
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