2. Anti-infection
  3. Fungal
  4. Poacic acid

Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants.

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Poacic acid Chemical Structure

Poacic acid Chemical Structure

CAS No. : 160097-32-5

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Based on 1 publication(s) in Google Scholar

Poacic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Poacic Acid is a plant-derived stilbenoid with an antifungal activity. Poacic Acid localizes to the yeast cell wall and disrupts the production and assembly of β-1,3-glucan in the fungal cell walls. Poacic Acid exhibits fungicidal activity to Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants[1].

In Vitro

Poacic Acid (0-512 μg/ml 48h) exhibits significant growth inhibition of Saccharomyces cerevisiae at concentrations at or above 256 μg/mL. Poacic Acid also shows bactericidal effect on Candida albicans mutants with ERG11 and ERG3 gene deletion[1].
Poacic Acid (1 mM; 1-42 h) increases the production of chitin in the cell wall of Saccharomyces cerevisiae and altered its distribution[1].
Poacic Acid (512 μg/mL; 36 h) has a reduced inhibitory effect on Saccharomyces cerevisiae in the presence of additional β-glucan or chitin or metal ions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Poacic acid Related Antibodies
Molecular Weight

342.34

Formula

C19H18O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC(/C=C/C(O)=O)=CC(/C=C/C2=CC(OC)=C(C=C2)O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (292.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9211 mL 14.6054 mL 29.2107 mL
5 mM 0.5842 mL 2.9211 mL 5.8421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.21%

SDS (251 KB)

COA (246 KB) HNMR (257 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9211 mL 14.6054 mL 29.2107 mL 73.0268 mL
5 mM 0.5842 mL 2.9211 mL 5.8421 mL 14.6054 mL
10 mM 0.2921 mL 1.4605 mL 2.9211 mL 7.3027 mL
15 mM 0.1947 mL 0.9737 mL 1.9474 mL 4.8685 mL
20 mM 0.1461 mL 0.7303 mL 1.4605 mL 3.6513 mL
25 mM 0.1168 mL 0.5842 mL 1.1684 mL 2.9211 mL
30 mM 0.0974 mL 0.4868 mL 0.9737 mL 2.4342 mL
40 mM 0.0730 mL 0.3651 mL 0.7303 mL 1.8257 mL
50 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4605 mL
60 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2171 mL
80 mM 0.0365 mL 0.1826 mL 0.3651 mL 0.9128 mL
100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.7303 mL
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Poacic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Poacic acid160097-32-5FungalAntifungal activityCell wall inhibitorChitin production inducerMetal ion interactionInhibitorinhibitorinhibit

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