2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Pol I-IN-1

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194.

For research use only. We do not sell to patients.

Pol I-IN-1 Chemical Structure

Pol I-IN-1 Chemical Structure

CAS No. : 2765318-69-0

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Pol I-IN-1 Related Antibodies

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Description

Pol I-IN-1 is a potent RNA polymerase I (Pol I) inhibitor with IC50 0.21 µM for the Pol I large catalytic subunit RPA194[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
38 nM
Compound: 31
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent assay
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent assay
[PMID: 35450366]
Molecular Weight

386.45

Formula

C23H22N4O2
CAS No.
SMILES

O=C(C1=CC=CN2C(C3=C(C4=C(C=C3)C=CC=C4)N=C12)=O)NCCN5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pol I-IN-1 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pol I-IN-12765318-69-0DNA/RNA SynthesisInhibitorinhibitorinhibit

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