Polygalacic acid

Cat. No.: HY-N0801 Purity: 98.92%: FAQs
Data Sheet SDS COA Handling Instructions

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Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex.

For research use only. We do not sell to patients.

Polygalacic acid Chemical Structure

CAS No. : 22338-71-2

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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AChE BChE

Biological Activity
Purity & Documentation
References
Customer Review

Description

Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment ^[1]. Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex^[2].

IC₅₀ & Target

AChE

In Vitro

Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner^[1].
Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time:	24 hours
Result:	Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression.

Western Blot Analysis^[1]

Cell Line:	Chondrocyte cells
Concentration:	50 μM; 100 μM
Incubation Time:	6 hours
Result:	Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes.

Molecular Weight

504.70

Formula

C₃₀H₄₈O₆

CAS No.

22338-71-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@@]1([H])[C@]2(C[C@H](O)[C@@H]3O)C)(CC[C@@]2([H])[C@]3(C)CO)[C@@](C4=CC1)(C[C@@H](O)[C@]5(C(O)=O)[C@@]4([H])CC(C)(C)CC5)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (99.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9814 mL	9.9069 mL	19.8138 mL
5 mM	0.3963 mL	1.9814 mL	3.9628 mL
10 mM	0.1981 mL	0.9907 mL	1.9814 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (265 KB) RP-HPLC (144 KB) MS (287 KB)

Handling Instructions (2659 KB)

References

[1]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15;23(2):149-55. [Content Brief]

[2]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct;63:246-252. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9814 mL	9.9069 mL	19.8138 mL	49.5344 mL
	5 mM	0.3963 mL	1.9814 mL	3.9628 mL	9.9069 mL
	10 mM	0.1981 mL	0.9907 mL	1.9814 mL	4.9534 mL
	15 mM	0.1321 mL	0.6605 mL	1.3209 mL	3.3023 mL
	20 mM	0.0991 mL	0.4953 mL	0.9907 mL	2.4767 mL
	25 mM	0.0793 mL	0.3963 mL	0.7926 mL	1.9814 mL
	30 mM	0.0660 mL	0.3302 mL	0.6605 mL	1.6511 mL
	40 mM	0.0495 mL	0.2477 mL	0.4953 mL	1.2384 mL
	50 mM	0.0396 mL	0.1981 mL	0.3963 mL	0.9907 mL
	60 mM	0.0330 mL	0.1651 mL	0.3302 mL	0.8256 mL
	80 mM	0.0248 mL	0.1238 mL	0.2477 mL	0.6192 mL