Polygalacin D3

Cat. No.: HY-N13164: FAQs
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Polygalacin D3 is a triterpenoid saponin compound that can be extracted from the roots of the balloon flower. Polygalacin D3 can inhibit the proliferation of non-small cell lung cancer (NSCLC) cell lines by blocking the PI3K/Akt pathway, and it induces cell cycle arrest and cell apoptosis.

For research use only. We do not sell to patients.

Polygalacin D3 Chemical Structure

CAS No. : 849758-44-7

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Akt Akt1 Akt2 Akt3

Biological Activity
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Description	Polygalacin D3 is a triterpenoid saponin compound that can be extracted from the roots of the balloon flower. Polygalacin D3 can inhibit the proliferation of non-small cell lung cancer (NSCLC) cell lines by blocking the PI3K/Akt pathway, and it induces cell cycle arrest and cell apoptosis^[1].
Molecular Weight	1371.46
Formula	C₆₃H₁₀₂O₃₂
CAS No.	849758-44-7
SMILES	O[C@H]([C@@H]([C@H]([C@@H](O1)C)O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O[C@H]3[C@@H]([C@](O)(CO3)CO)O)O)O)[C@@H]1O[C@H]([C@H]([C@H](CO4)O)O)[C@@H]4OC([C@]56[C@](CC(C)(CC6)C)([H])C7=CC[C@@]([C@@]8([C@@]([C@@](C)([C@H]([C@H](C8)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC%11)C)([H])[C@]%11(C)[C@@]7(C[C@H]5O)C)=O
Structure Classification	Terpenoids Triterpenes
Initial Source	Plants Campanulaceae Platycodon grandiflorus (Jacq.) A. DC.
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Seo YS, et al. Polygalacin D induces apoptosis and cell cycle arrest via the PI3K/Akt pathway in non-small cell lung cancer. Oncol Rep. 2018 Apr;39(4):1702-1710. [Content Brief]

Polygalacin D3 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polygalacin D3849758-44-7Polygalacin D 3Polygalacin D-3PI3KAktApoptosisPhosphoinositide 3-kinasePKBProtein kinase Btriterpenoid saponinPI3K/AktNSCLCapoptosisInhibitorinhibitorinhibit

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