2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide 4'-alkylC5-acid

Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC.

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Pomalidomide 4'-alkylC5-acid Chemical Structure

Pomalidomide 4'-alkylC5-acid Chemical Structure

CAS No. : 2225940-49-6

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Based on 1 publication(s) in Google Scholar

Pomalidomide 4'-alkylC5-acid Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC[1].

IC50 & Target

Cereblon

 

Molecular Weight

387.39

Formula

C19H21N3O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (129.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5814 mL 12.9069 mL 25.8138 mL
5 mM 0.5163 mL 2.5814 mL 5.1628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.78%

COA (248 KB) HNMR (231 KB) LCMS (123 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5814 mL 12.9069 mL 25.8138 mL 64.5344 mL
5 mM 0.5163 mL 2.5814 mL 5.1628 mL 12.9069 mL
10 mM 0.2581 mL 1.2907 mL 2.5814 mL 6.4534 mL
15 mM 0.1721 mL 0.8605 mL 1.7209 mL 4.3023 mL
20 mM 0.1291 mL 0.6453 mL 1.2907 mL 3.2267 mL
25 mM 0.1033 mL 0.5163 mL 1.0326 mL 2.5814 mL
30 mM 0.0860 mL 0.4302 mL 0.8605 mL 2.1511 mL
40 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6134 mL
50 mM 0.0516 mL 0.2581 mL 0.5163 mL 1.2907 mL
60 mM 0.0430 mL 0.2151 mL 0.4302 mL 1.0756 mL
80 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8067 mL
100 mM 0.0258 mL 0.1291 mL 0.2581 mL 0.6453 mL
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Pomalidomide 4'-alkylC5-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide 4'-alkylC5-acid2225940-49-6E3 Ligase Ligand-Linker ConjugatesPROTACcancerCRBNpomalidomideInhibitorinhibitorinhibit

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